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    古丽娟 麻醉学
    教授，博士生导师
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    科室及职务

    诊疗专长

    姓名 古丽娟
    出生年月 1973年9月
    单位 武汉大学人民医院中心实验室
    所属学科 临床医学-麻醉学
    职务、职称及头衔 教授，博士生导师
    E-mail gulijuan@whu.edu.cn
    联系方式 15271921282
    研究方向 1.缺血性脑卒中的发病机制：主要关注缺血性脑卒中的免疫学发生机制，尤其是淋巴细胞在缺血性脑卒中中的作用和机制研究。
    2.缺血性脑卒中对免疫系统的影响：关注缺血性脑卒中对外周脏器的影响，例如脾脏、肺脏和外周免疫系统；重点研究和探索缺血性脑卒中诱导的外周免疫抑制的发生机制和靶向干预措施。
    个人简介
    浙江大学与美国斯坦福大学医学院联合培养博士，主要从事脑缺血再灌注损伤后脑组织炎症反应和外周免疫抑制的发生机制及二者相互关系研究，以期开发有效的神经保护措施；获得国家自然科学基金资助5项、湖北省自然科学基金资助1项；发表论文近80篇，其中包括神经科学Top杂志《Stroke》等在内的SCI论文78篇；成果《缺血性脑损伤与免疫调控的机制与防治》获2020年湖北省科技进步三等奖；发表译著《探索对与错的真相：重新审视麻醉学中的经典内容》；发表教学论文2篇，主持武汉大学医学部研究生教学项目1项；具有国内外指导本科生和研究生科研活动的丰富经验，指导本科生以及硕士、博士研究生40余人，其中21人已顺利毕业，并能为学生进一步出国深造提供帮助。
    学术任职与荣誉
    湖北省医学生物免疫学会神经免疫专委会委员
    《Frontiers in immunology》专题（Special Issue）客座编辑
    《Frontiers in Neurology》、《Translational Stroke Research》、《Brain Research》等杂志审稿专家
    《武汉大学学报（医学版）》英文审校和审稿专家
    教育履历
    1991.09-1996.07山西医科大学临床医学专业本科生获学士学位
    2002.09-2005.06浙江大学医学院内科学硕士研究生获硕士学位
    2006.09-2012.06浙江大学医学院免疫学博士研究生获博士学位
    工作履历
    1996.07-2002.08山西省阳泉市第一人民医院神经内科住院及主治医师
    2009.01-2012.02美国斯坦福大学医学院神经外科，研究助理(Department of Neurosurgery，Stanford University School of Medicine，Joint Ph.D and Research Assistant)
    2012.08-2014.10杭州师范大学医学院病理学教研室，讲师（人才引进）
    2014.11-2022.11武汉大学人民医院中心实验室，副教授（人才引进） 2022.12至今武汉大学人民医院中心实验室，教授
    成果获奖
    《缺血性脑损伤与免疫调控的机制与防治》2020年获湖北省科技进步三等奖
    代表性论著
    1.Tian Q#, Liu CL#, Liao JM#, Wang GJ, Han WR, Xiong XX, Chen ZB*, Gu LJ*, Li MC*. ATF2/BAP1 axis mediates neuronal apoptosis after subarachnoid hemorrhage via P53 pathway. Stroke. 2024. (*通讯作者）
    2.Jian ZH#, Ye YZ#, Yu K#, Wei Hu W, Zhu H, Wang J, Xiong XX*, Li CY*, Gu LJ*. Ratiometric two-photon fluorescent probe for imaging hydrogen peroxide during stroke-induced ferroptosis. Sensor Actuat B-Chem.2024；417：136064 (*通讯作者）
    3.Zhao B, Li M, Li BY, Li YN, Shen QN, Hou JB,Wu Y, Gu LJ*, GaoWW*. CTRP6 alleviates cerebral ischemia-reperfusion injury in diabetic mice via activating Sirt1 signaling pathway. Neural Regen Res. 2024.19(9):2019-2026.（*通讯作者）
    4.Li YN, Gao YK, Feng S, Gu LJ*. Bibliometric and visualization analysis of matrix metalloproteinases in ischemic stroke from 1992 to 2022. frontiers in neuroscience. Front in Neurosci. 2024.19(3):611-618（*通讯作者）
    5. Tian Q#, Li YN#, Feng S, Liu CL , Guo YJ, Wang GJ, Wei H, Chen ZB*, Gu LJ*, Li MC*. Inhibition of CCR1 attenuates neuroinflammation via the JAK2/STAT3 signaling pathway after subarachnoid hemorrhage. Int Immunopharmacol. 2023 Dec;125(Pt A). (*通讯作者）
    6. Feng S, Zhang YG, Zhu H, Jian ZH, Zeng Z, Ye YZ, Li YN, Smerin D, Zhang X, Zou N*, Gu LJ*, Xiong XX*. Cuproptosis facilitates immune activation but promotes immune escape and a machine learning-based Cuproptosis-related signature is identified for predicting prognosis and immunotherapy response of gliomas. CNS Neurosci Ther. 2023 July.（*通讯作者）
    7. Zhu H, Zhang YG, Feng S, Li YN, Ye YZ, Jian ZH*, Xiong XX*, Gu LJ*. Trends in NLRP3 Inflammasome research in ischemic stroke from 2011 to 2022: A bibliometric analysis. CNS Neurosci Ther. 2023 Apr 23.（*通讯作者）
    8. Zhu H, Zhong Y, Chen R, Wang L, Li YT, Jian ZH, Gu LJ*, Xiong XX*. ATG5 Knockdown Attenuates Ischemia‒Reperfusion Injury by Reducing Excessive Autophagy-Induced Ferroptosis. Transl Stroke Res. 2022 Dec 16.（*通讯作者）
    9. Wang Z, Li YN, Ye YZ, Zhu H, Zhang J, Wang HJ, Lei JX, Gu LJ*, Zhan LY*. NLRP3 inflammasome deficiency attenuates cerebral ischemia-reperfusion injury by inhibiting ferroptosis. Brain Res Bull, 2022;193:37-46.（*通讯作者）
    10. Wang JC, Zhong Y, Mahgoub OK, Jian ZH, Gu LJ*, Xiong XX*. Different gender-derived gut microbiota influence stroke outcomes by mitigatinginflammation. J Neuroinflamm. 2022; 19(1):245（*通讯作者）
    11. Xiong XX, Ye YZ, Gao XY, Zhu H, Hu W, Li CY, Jian ZH, Deng HP*, Gu LJ*, An ultrasensitive fluorescent platform for monitoring GSH variation during ischemic stroke. Chem Eng J. 2022; 137931（*通讯作者）
    12. Wang J,Zhang JH,Ye YZ,Xu QX, Li YN,Feng S,Xiong XX,Jian ZH*, Gu LJ*. Peripheral organs injury after stroke. Front Immunol. 2022;13:901209. Front Immunol（*通讯作者）
    13. Zhong Y#, Gu LJ#, Ye YZ, Zhu H, Pu B, Wang JC, Li YT, Qiu S, Jian ZH*, Xiong XX*. JAK2/STAT3 Axis Intermediates Microglia/Macrophage Polarization During Cerebral Ischemia/Reperfusion Injury. Neuroscience. 2022;496:119-128.（#共同第一作者）
    14. Liu YS, Li QQ, Gu MJ, Lu DS, Xiong XX, Zhang ZY, Pan YN, Liao YQ, Ding QH, Gong WX, Chen SL, Guan MT, Wu JZ, Tian ZQ, Deng H, Gu LJ*, Hong XC*, Xiao YL*. A second Near-Infrared Ru (II) Polypyridyl complex for synergistic chemo-photothermal therapy. J Med Chem. 2022;65(3):2225-2237（*通讯作者）
    15. Zhu H,Hu XY,Ye YZ,Jian ZH, Zhong Y,Gu LJ*,Xiong XX*.Pan-Cancer Analysis of PIMREG as a Biomarker for the Prognostic and Immunological Role. Front Genet. 2021 Sep 14; 12:687778（*通讯作者)
    16. Zhu H, Jian ZH, Zhong Y, Ye YZ, Zhang YG, Hu XY, Pu B, Gu LJ*, Xiong XX*. Janus Kinase Inhibition Ameliorates Ischemic Stroke Injury and Neuroinflammation through Reducing NLRP3 Inflammasome Activation via JAK2/STAT3 Pathway Inhibition. Front Immunol. 2021.714943（*通讯作者)
    17. Xu QX, Zhao B, Ye YZ, Li YN, Zhang YG, Xiong XX*, Gu LJ*. Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke. J Neuroinflamm. 2021;18: 123（*通讯作者)
    18. Zhu H, Zhang YG, Zhong Y, Ye YZ, Hu XY, Xiong XX*, Gu LJ*. Inflammation-mediated angiogenesis in ischemic stroke. Front Cell Neurosci. 2021.652647（*通讯作者)
    19. WangL,XiongXX,ZhangX,YeYZ,JianZH,GaoWW*,GuLJ*. Sodium Tanshinone IIA Sulfonate protects against cerebral ischemia–reperfusion injury by inhibiting autophagy and inflammation. Neuroscience. 2020;441:46-57.（*通讯作者)
    20. Ye YZ, Jin T, Zhang X, Zeng Z, Ye BX, Wang JC, Zhong Y, Xiong XX*, Gu LJ*. Meisoindigo protects againstfocal cerebral ischemia-reperfusion injury by inhibiting NLRP3 inflammasome activation and regulating microglia/macrophage polarization via TLR4/NF-κB aignaling pathway. Front Cell Neurosci. 2019;13: 553.（*通讯作者)
    21. Xiong XX#, Gu LJ#, Wang Y, Luo Y, Zhang HF, Lee J, Krams SM, Zhu SM, Zhao H. Glycyrrhizin protects against focal cerebral ischemia via inhibition of T cell activity and HMGB1-mediated mechanisms. J Neuroinflammation. 2016 Sep 8;13(1):241（#共同第一作者)
    22. Gu LJ, Xiong XX, Ito T, Lee J, Xu BH, Krams S, Steinberg GK, Zhao H. Moderate hypothermia inhibits brain inflammation and attenuates stroke-induced immunodepression in rats. CNS Neurosci Ther. 2014; 20:67-75.
    23. Gu LJ, Xiong XX, Zhang HF, Xu BH, Steinberg GK, Zhao H. Distinctive effects of t cell subsets in neuronal injury induced by cocultured splenocytes in vitro and by in vivo stroke in mice. Stroke. 2012; 43:1941-1946.
    Name LIJUAN GU
    Date of birth September, 1973
    Department Central laboratory, Renmin Hospital,Wuhan University
    Title Professor, doctoral tutor
    Email gulijuan@whu.edu.cn
    TEL 15271921282
    Research Direction
    1.Pathogenesis of cerebral ischemia: Mainly focuses on the immunological mechanisms of cerebral ischemia, and to explore the effects and mechanisms of T lymphocytes on the brain after cerebral ischemia/reperfusion injury.
    2.The effects of cerebral inchemia on immune system: to investigate the mechanisms of stroke induced immunodepression (SIID) and explore targeted interventions. 
    Personal Profile
    She is mainly engaged in studying the mechanisms of brain inflammation and peripheral immunosuppression after ischemic stroke and clarifying the interaction between them, thus exploring effective neuronal protective drugs for stroke treatment. She had a career as an Joint-PhD and research assistant working at Stanford University for three years. To date, she has been awarded 5 items from the National Natural Science Foundation, and there are a translation book and 78 papers published in the SCI journals including the top level journal STROKE and JOURNAL OF NEUROINFLAMMATION.  Her research achivement, "Mechanism and Prevention of Ischemic Brain Injury and Immune Regulation", won the prize of Scientific and Technological Progress of Hubei Province in 2020.  She also has published 2 teaching papers and presided over 1 postgraduate teaching project of Medical department of Wuhan University.  Besides, she has been invited to be a reviewer for Frontiers in Neurology and Translational Stroke Research, etc, as well as an English editor and special reviewer for MEDICAL JOURNAL OF WUHAN UNIVERSITY. She also has been invited to be a guest editor to take charge of a special issue in Frontiers in Immunology. In addition, she has rich experience in guiding undergraduate and postgraduate students at home and abroad. She also can help students to go abroad for further study.  
    Selected Publications
    1.Tian Q#, Liu CL#, Liao JM#, Wang GJ, Han WR, Xiong XX, Chen ZB*, Gu LJ*, Li MC*. ATF2/BAP1 axis mediates neuronal apoptosis after subarachnoid hemorrhage via P53 pathway. Stroke. 2024. (*通讯作者）
    2.Jian ZH#, Ye YZ#, Yu K#, Wei Hu W, Zhu H, Wang J, Xiong XX*, Li CY*, Gu LJ*. Ratiometric two-photon fluorescent probe for imaging hydrogen peroxide during stroke-induced ferroptosis. Sensor Actuat B-Chem.2024；417：136064 (*通讯作者）              
    3.Zhao B, Li M, Li BY, Li YN, Shen QN, Hou JB,Wu Y, Gu LJ*, GaoWW*. CTRP6 alleviates cerebral ischemia-reperfusion injury in diabetic mice via activating Sirt1 signaling pathway. Neural Regen Res. 2024.19(9):2019-2026.（*通讯作者）  
    4.Li YN, Gao YK, Feng S, Gu LJ*. Bibliometric and visualization analysis of matrix metalloproteinases in ischemic stroke from 1992 to 2022. frontiers in neuroscience. Front in Neurosci. 2024.19(3):611-618（*通讯作者）
    5. Tian Q#, Li YN#, Feng S, Liu CL , Guo YJ, Wang GJ, Wei H, Chen ZB*, Gu LJ*, Li MC*. Inhibition of CCR1 attenuates neuroinflammation via the JAK2/STAT3 signaling pathway after subarachnoid hemorrhage. Int Immunopharmacol.  2023 Dec;125(Pt A). (*通讯作者）
    6. Feng S, Zhang YG, Zhu H, Jian ZH, Zeng Z, Ye YZ, Li YN, Smerin D, Zhang X, Zou N*, Gu LJ*, Xiong XX*. Cuproptosis facilitates immune activation but promotes immune escape and a machine learning-based Cuproptosis-related signature is identified for predicting prognosis and immunotherapy response of gliomas. CNS Neurosci Ther. 2023 July.（*通讯作者）
    7. Zhu H, Zhang YG, Feng S, Li YN, Ye YZ, Jian ZH*, Xiong XX*, Gu LJ*. Trends in NLRP3 Inflammasome research in ischemic stroke from 2011 to 2022: A bibliometric analysis. CNS Neurosci Ther. 2023 Apr 23.（*通讯作者）
    8. Zhu H, Zhong Y, Chen R, Wang L, Li YT, Jian ZH, Gu LJ*, Xiong XX*. ATG5 Knockdown Attenuates Ischemia‒Reperfusion Injury by Reducing Excessive Autophagy-Induced Ferroptosis. Transl Stroke Res. 2022 Dec 16.（*通讯作者）
    9. Wang Z, Li YN, Ye YZ, Zhu H, Zhang J, Wang HJ, Lei JX, Gu LJ*, Zhan LY*. NLRP3 inflammasome deficiency attenuates cerebral ischemia-reperfusion injury by inhibiting ferroptosis. Brain Res Bull, 2022;193:37-46. （*通讯作者）
    10. Wang JC, Zhong Y, Mahgoub OK, Jian ZH, Gu LJ*, Xiong XX*. Different gender-derived gut microbiota influence stroke outcomes by mitigating inflammation. J Neuroinflamm. 2022; 19(1):245（*通讯作者）
    11. Xiong XX, Ye YZ, Gao XY, Zhu H, Hu W, Li CY, Jian ZH, Deng HP*, Gu LJ*, An ultrasensitive fluorescent platform for monitoring GSH variation during ischemic stroke. Chem Eng J. 2022; 137931（*通讯作者）
    12. Wang J, Zhang JH, Ye YZ, Xu QX, Li YN, Feng S, Xiong XX, Jian ZH*, Gu LJ*. Peripheral organs injury after stroke. Front Immunol. 2022;13:901209. Front Immunol（*通讯作者）
    13. Zhong Y#, Gu LJ#, Ye YZ, Zhu H, Pu B, Wang JC, Li YT, Qiu S, Jian ZH*, Xiong XX*. JAK2/STAT3 Axis Intermediates Microglia/Macrophage Polarization During Cerebral Ischemia/Reperfusion Injury. Neuroscience. 2022;496:119-128.（#共同第一作者）
    14. Liu YS, Li QQ, Gu MJ, Lu DS, Xiong XX, Zhang ZY, Pan YN, Liao YQ, Ding QH, Gong WX, Chen SL, Guan MT, Wu JZ, Tian ZQ, Deng H, Gu LJ*, Hong XC*, Xiao YL*. A second Near-Infrared Ru (II) Polypyridyl complex for synergistic chemo-photothermal therapy. J Med Chem. 2022;65(3):2225-2237（*通讯作者）
    15. Zhu H, Hu XY, Ye YZ, Jian ZH, Zhong Y, Gu LJ*, Xiong XX*. Pan-Cancer Analysis of PIMREG as a Biomarker for the Prognostic and Immunological Role. Front Genet. 2021 Sep 14; 12:687778（*通讯作者)
    16. Zhu H, Jian ZH, Zhong Y, Ye YZ, Zhang YG, Hu XY, Pu B, Gu LJ*, Xiong XX*. Janus Kinase Inhibition Ameliorates Ischemic Stroke Injury and Neuroinflammation through Reducing NLRP3 Inflammasome Activation via JAK2/STAT3 Pathway Inhibition. Front Immunol. 2021.714943（*通讯作者)
    17. Xu QX, Zhao B, Ye YZ, Li YN, Zhang YG, Xiong XX*, Gu LJ*. Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke. J Neuroinflamm. 2021; 18: 123（*通讯作者)
    18. Zhu H, Zhang YG, Zhong Y, Ye YZ, Hu XY, Xiong XX*, Gu LJ*. Inflammation-mediated angiogenesis in ischemic stroke. Front Cell Neurosci. 2021.652647（*通讯作者)
    19. Wang L, Xiong XX, Zhang X, Ye YZ, Jian ZH, Gao WW*, Gu LJ*. Sodium Tanshinone IIA Sulfonate protects against cerebral ischemia–reperfusion injury by inhibiting autophagy and inflammation. Neuroscience. 2020;441:46-57.（*通讯作者)
    20. Ye YZ, Jin T, Zhang X, Zeng Z, Ye BX, Wang JC, Zhong Y, Xiong XX*, Gu LJ*. Meisoindigo protects againstfocal cerebral ischemia-reperfusion injury by inhibiting NLRP3 inflammasome activation and regulating microglia/macrophage polarization via TLR4/NF-κB aignaling pathway. Front Cell Neurosci. 2019; 13: 553.（*通讯作者)
    21. Xiong XX#, Gu LJ#, Wang Y, Luo Y, Zhang HF, Lee J, Krams SM, Zhu SM, Zhao H. Glycyrrhizin protects against focal cerebral ischemia via inhibition of T cell activity and HMGB1-mediated mechanisms. J Neuroinflammation. 2016 Sep 8;13(1):241（#共同第一作者)
    22. Gu LJ, Xiong XX, Ito T, Lee J, Xu BH, Krams S, Steinberg GK, Zhao H. Moderate hypothermia inhibits brain inflammation and attenuates stroke-induced immunodepression in rats. CNS Neurosci Ther. 2014; 20:67-75.
    23. Gu LJ, Xiong XX, Zhang HF, Xu BH, Steinberg GK, Zhao H. Distinctive effects of t cell subsets in neuronal injury induced by cocultured splenocytes in vitro and by in vivo stroke in mice. Stroke. 2012; 43:1941-1946.

    学术任职与荣誉

    科研成果

    出诊医生 星期一 星期二 星期三 星期四 星期五 星期六 星期日
    上午 下午 上午 下午 上午 下午 上午 下午 上午 下午 上午 下午 上午 下午
    古丽娟
    预约方式

    古丽娟

    麻醉学

    教授，博士生导师

    诊疗专长：

    姓名 古丽娟
    出生年月 1973年9月
    单位 武汉大学人民医院中心实验室
    所属学科 临床医学-麻醉学
    职务、职称及头衔 教授，博士生导师
    E-mail gulijuan@whu.edu.cn
    联系方式 15271921282
    研究方向 1.缺血性脑卒中的发病机制：主要关注缺血性脑卒中的免疫学发生机制，尤其是淋巴细胞在缺血性脑卒中中的作用和机制研究。
    2.缺血性脑卒中对免疫系统的影响：关注缺血性脑卒中对外周脏器的影响，例如脾脏、肺脏和外周免疫系统；重点研究和探索缺血性脑卒中诱导的外周免疫抑制的发生机制和靶向干预措施。
    个人简介
    浙江大学与美国斯坦福大学医学院联合培养博士，主要从事脑缺血再灌注损伤后脑组织炎症反应和外周免疫抑制的发生机制及二者相互关系研究，以期开发有效的神经保护措施；获得国家自然科学基金资助5项、湖北省自然科学基金资助1项；发表论文近80篇，其中包括神经科学Top杂志《Stroke》等在内的SCI论文78篇；成果《缺血性脑损伤与免疫调控的机制与防治》获2020年湖北省科技进步三等奖；发表译著《探索对与错的真相：重新审视麻醉学中的经典内容》；发表教学论文2篇，主持武汉大学医学部研究生教学项目1项；具有国内外指导本科生和研究生科研活动的丰富经验，指导本科生以及硕士、博士研究生40余人，其中21人已顺利毕业，并能为学生进一步出国深造提供帮助。
    学术任职与荣誉
    湖北省医学生物免疫学会神经免疫专委会委员
    《Frontiers in immunology》专题（Special Issue）客座编辑
    《Frontiers in Neurology》、《Translational Stroke Research》、《Brain Research》等杂志审稿专家
    《武汉大学学报（医学版）》英文审校和审稿专家
    教育履历
    1991.09-1996.07山西医科大学临床医学专业本科生获学士学位
    2002.09-2005.06浙江大学医学院内科学硕士研究生获硕士学位
    2006.09-2012.06浙江大学医学院免疫学博士研究生获博士学位
    工作履历
    1996.07-2002.08山西省阳泉市第一人民医院神经内科住院及主治医师
    2009.01-2012.02美国斯坦福大学医学院神经外科，研究助理(Department of Neurosurgery，Stanford University School of Medicine，Joint Ph.D and Research Assistant)
    2012.08-2014.10杭州师范大学医学院病理学教研室，讲师（人才引进）
    2014.11-2022.11武汉大学人民医院中心实验室，副教授（人才引进） 2022.12至今武汉大学人民医院中心实验室，教授
    成果获奖
    《缺血性脑损伤与免疫调控的机制与防治》2020年获湖北省科技进步三等奖
    代表性论著
    1.Tian Q#, Liu CL#, Liao JM#, Wang GJ, Han WR, Xiong XX, Chen ZB*, Gu LJ*, Li MC*. ATF2/BAP1 axis mediates neuronal apoptosis after subarachnoid hemorrhage via P53 pathway. Stroke. 2024. (*通讯作者）
    2.Jian ZH#, Ye YZ#, Yu K#, Wei Hu W, Zhu H, Wang J, Xiong XX*, Li CY*, Gu LJ*. Ratiometric two-photon fluorescent probe for imaging hydrogen peroxide during stroke-induced ferroptosis. Sensor Actuat B-Chem.2024；417：136064 (*通讯作者）
    3.Zhao B, Li M, Li BY, Li YN, Shen QN, Hou JB,Wu Y, Gu LJ*, GaoWW*. CTRP6 alleviates cerebral ischemia-reperfusion injury in diabetic mice via activating Sirt1 signaling pathway. Neural Regen Res. 2024.19(9):2019-2026.（*通讯作者）
    4.Li YN, Gao YK, Feng S, Gu LJ*. Bibliometric and visualization analysis of matrix metalloproteinases in ischemic stroke from 1992 to 2022. frontiers in neuroscience. Front in Neurosci. 2024.19(3):611-618（*通讯作者）
    5. Tian Q#, Li YN#, Feng S, Liu CL , Guo YJ, Wang GJ, Wei H, Chen ZB*, Gu LJ*, Li MC*. Inhibition of CCR1 attenuates neuroinflammation via the JAK2/STAT3 signaling pathway after subarachnoid hemorrhage. Int Immunopharmacol. 2023 Dec;125(Pt A). (*通讯作者）
    6. Feng S, Zhang YG, Zhu H, Jian ZH, Zeng Z, Ye YZ, Li YN, Smerin D, Zhang X, Zou N*, Gu LJ*, Xiong XX*. Cuproptosis facilitates immune activation but promotes immune escape and a machine learning-based Cuproptosis-related signature is identified for predicting prognosis and immunotherapy response of gliomas. CNS Neurosci Ther. 2023 July.（*通讯作者）
    7. Zhu H, Zhang YG, Feng S, Li YN, Ye YZ, Jian ZH*, Xiong XX*, Gu LJ*. Trends in NLRP3 Inflammasome research in ischemic stroke from 2011 to 2022: A bibliometric analysis. CNS Neurosci Ther. 2023 Apr 23.（*通讯作者）
    8. Zhu H, Zhong Y, Chen R, Wang L, Li YT, Jian ZH, Gu LJ*, Xiong XX*. ATG5 Knockdown Attenuates Ischemia‒Reperfusion Injury by Reducing Excessive Autophagy-Induced Ferroptosis. Transl Stroke Res. 2022 Dec 16.（*通讯作者）
    9. Wang Z, Li YN, Ye YZ, Zhu H, Zhang J, Wang HJ, Lei JX, Gu LJ*, Zhan LY*. NLRP3 inflammasome deficiency attenuates cerebral ischemia-reperfusion injury by inhibiting ferroptosis. Brain Res Bull, 2022;193:37-46.（*通讯作者）
    10. Wang JC, Zhong Y, Mahgoub OK, Jian ZH, Gu LJ*, Xiong XX*. Different gender-derived gut microbiota influence stroke outcomes by mitigatinginflammation. J Neuroinflamm. 2022; 19(1):245（*通讯作者）
    11. Xiong XX, Ye YZ, Gao XY, Zhu H, Hu W, Li CY, Jian ZH, Deng HP*, Gu LJ*, An ultrasensitive fluorescent platform for monitoring GSH variation during ischemic stroke. Chem Eng J. 2022; 137931（*通讯作者）
    12. Wang J,Zhang JH,Ye YZ,Xu QX, Li YN,Feng S,Xiong XX,Jian ZH*, Gu LJ*. Peripheral organs injury after stroke. Front Immunol. 2022;13:901209. Front Immunol（*通讯作者）
    13. Zhong Y#, Gu LJ#, Ye YZ, Zhu H, Pu B, Wang JC, Li YT, Qiu S, Jian ZH*, Xiong XX*. JAK2/STAT3 Axis Intermediates Microglia/Macrophage Polarization During Cerebral Ischemia/Reperfusion Injury. Neuroscience. 2022;496:119-128.（#共同第一作者）
    14. Liu YS, Li QQ, Gu MJ, Lu DS, Xiong XX, Zhang ZY, Pan YN, Liao YQ, Ding QH, Gong WX, Chen SL, Guan MT, Wu JZ, Tian ZQ, Deng H, Gu LJ*, Hong XC*, Xiao YL*. A second Near-Infrared Ru (II) Polypyridyl complex for synergistic chemo-photothermal therapy. J Med Chem. 2022;65(3):2225-2237（*通讯作者）
    15. Zhu H,Hu XY,Ye YZ,Jian ZH, Zhong Y,Gu LJ*,Xiong XX*.Pan-Cancer Analysis of PIMREG as a Biomarker for the Prognostic and Immunological Role. Front Genet. 2021 Sep 14; 12:687778（*通讯作者)
    16. Zhu H, Jian ZH, Zhong Y, Ye YZ, Zhang YG, Hu XY, Pu B, Gu LJ*, Xiong XX*. Janus Kinase Inhibition Ameliorates Ischemic Stroke Injury and Neuroinflammation through Reducing NLRP3 Inflammasome Activation via JAK2/STAT3 Pathway Inhibition. Front Immunol. 2021.714943（*通讯作者)
    17. Xu QX, Zhao B, Ye YZ, Li YN, Zhang YG, Xiong XX*, Gu LJ*. Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke. J Neuroinflamm. 2021;18: 123（*通讯作者)
    18. Zhu H, Zhang YG, Zhong Y, Ye YZ, Hu XY, Xiong XX*, Gu LJ*. Inflammation-mediated angiogenesis in ischemic stroke. Front Cell Neurosci. 2021.652647（*通讯作者)
    19. WangL,XiongXX,ZhangX,YeYZ,JianZH,GaoWW*,GuLJ*. Sodium Tanshinone IIA Sulfonate protects against cerebral ischemia–reperfusion injury by inhibiting autophagy and inflammation. Neuroscience. 2020;441:46-57.（*通讯作者)
    20. Ye YZ, Jin T, Zhang X, Zeng Z, Ye BX, Wang JC, Zhong Y, Xiong XX*, Gu LJ*. Meisoindigo protects againstfocal cerebral ischemia-reperfusion injury by inhibiting NLRP3 inflammasome activation and regulating microglia/macrophage polarization via TLR4/NF-κB aignaling pathway. Front Cell Neurosci. 2019;13: 553.（*通讯作者)
    21. Xiong XX#, Gu LJ#, Wang Y, Luo Y, Zhang HF, Lee J, Krams SM, Zhu SM, Zhao H. Glycyrrhizin protects against focal cerebral ischemia via inhibition of T cell activity and HMGB1-mediated mechanisms. J Neuroinflammation. 2016 Sep 8;13(1):241（#共同第一作者)
    22. Gu LJ, Xiong XX, Ito T, Lee J, Xu BH, Krams S, Steinberg GK, Zhao H. Moderate hypothermia inhibits brain inflammation and attenuates stroke-induced immunodepression in rats. CNS Neurosci Ther. 2014; 20:67-75.
    23. Gu LJ, Xiong XX, Zhang HF, Xu BH, Steinberg GK, Zhao H. Distinctive effects of t cell subsets in neuronal injury induced by cocultured splenocytes in vitro and by in vivo stroke in mice. Stroke. 2012; 43:1941-1946.
    Name LIJUAN GU
    Date of birth September, 1973
    Department Central laboratory, Renmin Hospital,Wuhan University
    Title Professor, doctoral tutor
    Email gulijuan@whu.edu.cn
    TEL 15271921282
    Research Direction
    1.Pathogenesis of cerebral ischemia: Mainly focuses on the immunological mechanisms of cerebral ischemia, and to explore the effects and mechanisms of T lymphocytes on the brain after cerebral ischemia/reperfusion injury.
    2.The effects of cerebral inchemia on immune system: to investigate the mechanisms of stroke induced immunodepression (SIID) and explore targeted interventions. 
    Personal Profile
    She is mainly engaged in studying the mechanisms of brain inflammation and peripheral immunosuppression after ischemic stroke and clarifying the interaction between them, thus exploring effective neuronal protective drugs for stroke treatment. She had a career as an Joint-PhD and research assistant working at Stanford University for three years. To date, she has been awarded 5 items from the National Natural Science Foundation, and there are a translation book and 78 papers published in the SCI journals including the top level journal STROKE and JOURNAL OF NEUROINFLAMMATION.  Her research achivement, "Mechanism and Prevention of Ischemic Brain Injury and Immune Regulation", won the prize of Scientific and Technological Progress of Hubei Province in 2020.  She also has published 2 teaching papers and presided over 1 postgraduate teaching project of Medical department of Wuhan University.  Besides, she has been invited to be a reviewer for Frontiers in Neurology and Translational Stroke Research, etc, as well as an English editor and special reviewer for MEDICAL JOURNAL OF WUHAN UNIVERSITY. She also has been invited to be a guest editor to take charge of a special issue in Frontiers in Immunology. In addition, she has rich experience in guiding undergraduate and postgraduate students at home and abroad. She also can help students to go abroad for further study.  
    Selected Publications
    1.Tian Q#, Liu CL#, Liao JM#, Wang GJ, Han WR, Xiong XX, Chen ZB*, Gu LJ*, Li MC*. ATF2/BAP1 axis mediates neuronal apoptosis after subarachnoid hemorrhage via P53 pathway. Stroke. 2024. (*通讯作者）
    2.Jian ZH#, Ye YZ#, Yu K#, Wei Hu W, Zhu H, Wang J, Xiong XX*, Li CY*, Gu LJ*. Ratiometric two-photon fluorescent probe for imaging hydrogen peroxide during stroke-induced ferroptosis. Sensor Actuat B-Chem.2024；417：136064 (*通讯作者）              
    3.Zhao B, Li M, Li BY, Li YN, Shen QN, Hou JB,Wu Y, Gu LJ*, GaoWW*. CTRP6 alleviates cerebral ischemia-reperfusion injury in diabetic mice via activating Sirt1 signaling pathway. Neural Regen Res. 2024.19(9):2019-2026.（*通讯作者）  
    4.Li YN, Gao YK, Feng S, Gu LJ*. Bibliometric and visualization analysis of matrix metalloproteinases in ischemic stroke from 1992 to 2022. frontiers in neuroscience. Front in Neurosci. 2024.19(3):611-618（*通讯作者）
    5. Tian Q#, Li YN#, Feng S, Liu CL , Guo YJ, Wang GJ, Wei H, Chen ZB*, Gu LJ*, Li MC*. Inhibition of CCR1 attenuates neuroinflammation via the JAK2/STAT3 signaling pathway after subarachnoid hemorrhage. Int Immunopharmacol.  2023 Dec;125(Pt A). (*通讯作者）
    6. Feng S, Zhang YG, Zhu H, Jian ZH, Zeng Z, Ye YZ, Li YN, Smerin D, Zhang X, Zou N*, Gu LJ*, Xiong XX*. Cuproptosis facilitates immune activation but promotes immune escape and a machine learning-based Cuproptosis-related signature is identified for predicting prognosis and immunotherapy response of gliomas. CNS Neurosci Ther. 2023 July.（*通讯作者）
    7. Zhu H, Zhang YG, Feng S, Li YN, Ye YZ, Jian ZH*, Xiong XX*, Gu LJ*. Trends in NLRP3 Inflammasome research in ischemic stroke from 2011 to 2022: A bibliometric analysis. CNS Neurosci Ther. 2023 Apr 23.（*通讯作者）
    8. Zhu H, Zhong Y, Chen R, Wang L, Li YT, Jian ZH, Gu LJ*, Xiong XX*. ATG5 Knockdown Attenuates Ischemia‒Reperfusion Injury by Reducing Excessive Autophagy-Induced Ferroptosis. Transl Stroke Res. 2022 Dec 16.（*通讯作者）
    9. Wang Z, Li YN, Ye YZ, Zhu H, Zhang J, Wang HJ, Lei JX, Gu LJ*, Zhan LY*. NLRP3 inflammasome deficiency attenuates cerebral ischemia-reperfusion injury by inhibiting ferroptosis. Brain Res Bull, 2022;193:37-46. （*通讯作者）
    10. Wang JC, Zhong Y, Mahgoub OK, Jian ZH, Gu LJ*, Xiong XX*. Different gender-derived gut microbiota influence stroke outcomes by mitigating inflammation. J Neuroinflamm. 2022; 19(1):245（*通讯作者）
    11. Xiong XX, Ye YZ, Gao XY, Zhu H, Hu W, Li CY, Jian ZH, Deng HP*, Gu LJ*, An ultrasensitive fluorescent platform for monitoring GSH variation during ischemic stroke. Chem Eng J. 2022; 137931（*通讯作者）
    12. Wang J, Zhang JH, Ye YZ, Xu QX, Li YN, Feng S, Xiong XX, Jian ZH*, Gu LJ*. Peripheral organs injury after stroke. Front Immunol. 2022;13:901209. Front Immunol（*通讯作者）
    13. Zhong Y#, Gu LJ#, Ye YZ, Zhu H, Pu B, Wang JC, Li YT, Qiu S, Jian ZH*, Xiong XX*. JAK2/STAT3 Axis Intermediates Microglia/Macrophage Polarization During Cerebral Ischemia/Reperfusion Injury. Neuroscience. 2022;496:119-128.（#共同第一作者）
    14. Liu YS, Li QQ, Gu MJ, Lu DS, Xiong XX, Zhang ZY, Pan YN, Liao YQ, Ding QH, Gong WX, Chen SL, Guan MT, Wu JZ, Tian ZQ, Deng H, Gu LJ*, Hong XC*, Xiao YL*. A second Near-Infrared Ru (II) Polypyridyl complex for synergistic chemo-photothermal therapy. J Med Chem. 2022;65(3):2225-2237（*通讯作者）
    15. Zhu H, Hu XY, Ye YZ, Jian ZH, Zhong Y, Gu LJ*, Xiong XX*. Pan-Cancer Analysis of PIMREG as a Biomarker for the Prognostic and Immunological Role. Front Genet. 2021 Sep 14; 12:687778（*通讯作者)
    16. Zhu H, Jian ZH, Zhong Y, Ye YZ, Zhang YG, Hu XY, Pu B, Gu LJ*, Xiong XX*. Janus Kinase Inhibition Ameliorates Ischemic Stroke Injury and Neuroinflammation through Reducing NLRP3 Inflammasome Activation via JAK2/STAT3 Pathway Inhibition. Front Immunol. 2021.714943（*通讯作者)
    17. Xu QX, Zhao B, Ye YZ, Li YN, Zhang YG, Xiong XX*, Gu LJ*. Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke. J Neuroinflamm. 2021; 18: 123（*通讯作者)
    18. Zhu H, Zhang YG, Zhong Y, Ye YZ, Hu XY, Xiong XX*, Gu LJ*. Inflammation-mediated angiogenesis in ischemic stroke. Front Cell Neurosci. 2021.652647（*通讯作者)
    19. Wang L, Xiong XX, Zhang X, Ye YZ, Jian ZH, Gao WW*, Gu LJ*. Sodium Tanshinone IIA Sulfonate protects against cerebral ischemia–reperfusion injury by inhibiting autophagy and inflammation. Neuroscience. 2020;441:46-57.（*通讯作者)
    20. Ye YZ, Jin T, Zhang X, Zeng Z, Ye BX, Wang JC, Zhong Y, Xiong XX*, Gu LJ*. Meisoindigo protects againstfocal cerebral ischemia-reperfusion injury by inhibiting NLRP3 inflammasome activation and regulating microglia/macrophage polarization via TLR4/NF-κB aignaling pathway. Front Cell Neurosci. 2019; 13: 553.（*通讯作者)
    21. Xiong XX#, Gu LJ#, Wang Y, Luo Y, Zhang HF, Lee J, Krams SM, Zhu SM, Zhao H. Glycyrrhizin protects against focal cerebral ischemia via inhibition of T cell activity and HMGB1-mediated mechanisms. J Neuroinflammation. 2016 Sep 8;13(1):241（#共同第一作者)
    22. Gu LJ, Xiong XX, Ito T, Lee J, Xu BH, Krams S, Steinberg GK, Zhao H. Moderate hypothermia inhibits brain inflammation and attenuates stroke-induced immunodepression in rats. CNS Neurosci Ther. 2014; 20:67-75.
    23. Gu LJ, Xiong XX, Zhang HF, Xu BH, Steinberg GK, Zhao H. Distinctive effects of t cell subsets in neuronal injury induced by cocultured splenocytes in vitro and by in vivo stroke in mice. Stroke. 2012; 43:1941-1946.



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