科室及职务
诊疗专长
| 姓名 | 林丹丹 |
| 出生年月 | 1986年2月 |
| 单位 | 武汉大学人民医院肿瘤科 |
| 所属学科 | 临床医学-肿瘤学 |
| 职务、职称及头衔 | 科副主任，主任医师，博士生导师 |
| 236772452@qq.com | |
| 联系方式 | 027-88041911转84324 |
| 研究方向 |
1.
消化道肿瘤的临床综合治疗 2. 肿瘤免疫微环境调控及靶向干预 |
| 个人简介 | |
| 主要研究方向为肿瘤内科治疗与肿瘤免疫微环境调节机制。先后赴美国芝加哥大学2011，美国德州西南医学中心2017-2018，北京医科院肿瘤医院2020等国内外临床诊疗与研究机构学习研修。主持国家自然科学基金3项，参与科技部重点研发计划1项，总经费超过200万元。近5年团队围绕感染免疫、炎症与消化道肿瘤的分子调节机制进行了深入研究，发现了多个蛋白调控免疫信号转导，从而调控感染免疫、炎症与肿瘤免疫等进展，并揭示了相关机制。先后主持国家自然科学基金3项，参与科技部重点研发计划项目1项。入选教育部青年国家级人才（2024），湖北省青年拔尖人才（2021），武汉市中青年医学骨干人才（2019），武汉大学青年拔尖人才（2017），武汉大学人民医院重点人才（2017）。迄今以第一或（共）通讯作者身份发表SCI论文14篇，包括 Nat Commun（2篇，IF 14.8），Cell Mol Immunol（2篇，IF 22.1），Adv Sci（3篇，IF 16.8），PNAS，Plos Pathog 及J Immunol等。 | |
| 学术任职与荣誉 | |
|
中华医学会伦理委员会 青年委员 湖北省肿瘤心理专业委员会 常务委员 湖北省抗癌协会肿瘤免疫治疗专业委员会 委员 湖北省医学生物免疫学会科普委员会 委员 湖北省微循环学会肿瘤专业委员会 委员 武汉市医学会肿瘤专业委员会 委员 |
|
| 教育履历 | |
|
2004-2012，武汉大学首届临床医学八年制毕业，博士学历 |
|
| 工作履历 | |
|
2012.07-2016.12 武汉大学人民医院肿瘤III科主治医师 2016.12-2020.07 武汉大学人民医院肿瘤III科副主任医师 2017.07-2018.06 美国西南医学中心放疗科国家公派访问学者 2019.07-2022.05 武汉大学人民医院肿瘤III科副主任医师、副教授、硕士生导师 2022.06-2024.06 武汉大学人民医院肿瘤III科副主任，主任医师，副教授，硕士生导师 |
|
| 成果获奖 | |
| 2024 教育部青年国家级人才 | |
| 代表性论著 | |
|
1．Dong HP, Li Y, Tang Z, Wang P, Zhong B, Chu Q, Lin D. Combined
targeting of CCL7 and Flt3L to promote the expansion and infiltration of
cDC1s in tumors enhances T-cell activation and anti-PD-1 therapy
effectiveness in NSCLC. Cell Mol Immunol. 2023 Jul;20(7):850-853. doi:
10.1038/s41423-023-00991-5. Epub 2023 Mar 9. PMID: 36894615; PMCID:
PMC10310796.IF:21.8 2．Zhang ZD, Shi CR, Li FX, Gan H, Wei Y, Zhang Q, Shuai X, Chen M, Lin YL, Xiong TC, Chen X, Zhong B, Lin D. Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115. Cell Mol Immunol. 2024 Mar;21(3):275-291. doi: 10.1038/s41423-024-01131-3. Epub 2024 Jan 24. PMID: 38267694; PMCID: PMC10901794.IF:21.8 3．Xiong TC, Wei MC, Li FX, Shi M, Gan H, Tang Z, Dong HP, Liuyu T, Gao P, Zhong B, Zhang ZD, Lin D. The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS. Nat Commun. 2022 Oct 10;13(1):5973. doi: 10.1038/s41467-022-33671-5. PMID: 36217001; PMCID: PMC9551088.IF:14.7 4. Zhang M, Yang W, Wang P, Deng Y, Dong YT, Liu FF, Huang R, Zhang P, Duan YQ, Liu XD, Lin D, Chu Q, Zhong B. CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer. Nat Commun. 2020 Nov 30;11(1):6119. doi: 10.1038/s41467-020-19973-6. PMID: 33257678; PMCID: PMC7704643.IF:14.7 5. Wang P, Yang W, Guo H, Dong HP, Guo YY, Gan H, Wang Z, Cheng Y, Deng Y, Xie S, Yang X, Lin D, Zhong B. IL-36γ and IL-36Ra Reciprocally Regulate NSCLC Progression by Modulating GSH Homeostasis and Oxidative Stress-Induced Cell Death. Adv Sci (Weinh). 2021 Oct;8(19):e2101501. doi: 10.1002/advs.202101501. Epub 2021 Aug 8. PMID: 34369094; PMCID: PMC8498882.IF:14.3 6. Yang W, Dong HP, Wang P, Xu ZG, Xian J, Chen J, Wu H, Lou Y, Lin D, Zhong B. IL-36γ and IL-36Ra Reciprocally Regulate Colon Inflammation and Tumorigenesis by Modulating the Cell-Matrix Adhesion Network and Wnt Signaling. Adv Sci (Weinh). 2022 Apr;9(10):e2103035. doi: 10.1002/advs.202103035. Epub 2022 Feb 4. PMID: 35119210; PMCID: PMC8981487.IF:14.3 7. Zhang ZD, Li HX, Gan H, Tang Z, Guo YY, Yao SQ, Liuyu T, Zhong B, Lin D. RNF115 Inhibits the Post-ER Trafficking of TLRs and TLRs-Mediated Immune Responses by Catalyzing K11-Linked Ubiquitination of RAB1A and RAB13. Adv Sci (Weinh). 2022 May;9(16):e2105391. doi: 10.1002/advs.202105391. Epub 2022 Mar 28. PMID: 35343654; PMCID: PMC9165487.IF:14.3 8. Ye L, Zhang Q, Liuyu T, Xu Z, Zhang MX, Luo MH, Zeng WB, Zhu Q, Lin D, Zhong B. USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA. PLoS Pathog. 2019 Apr 3;15(4):e1007680. doi: 10.1371/journal.ppat.1007680. PMID: 30943264; PMCID: PMC6464240.IF:5.5 |
| Name | DANDAN LIN |
| Date of birth | February,1986 |
| Department | Department of Oncology，Renmin Hospital,Wuhan University. |
| Title | Deputy Director, Chief Physician, Ph.D. Supervisor |
| 236772452@qq.com | |
| TEL | 027-88041911-84324 |
| Research Direction | |
|
1. Clinical Comprehensive Treatment of Gastrointestinal Tumors 2. Regulation and Targeted Intervention of the Tumor Immune Microenvironment |
|
| Personal Profile | |
| Her main research directions are the medical treatment of tumors and the regulatory mechanisms of the tumor immune microenvironment. She has studied and trained at the University of Chicago, USA (2011), the University of Texas, Southwestern Medical Center at Dallas,USA (2017-2018), and the Cancer Hospital of the Chinese Academy of Medical Sciences (2020). She has led three National Natural Science Foundation projects and participated in a key research program of the Ministry of Science and Technology, with total funding exceeding 2 million RMB. In the past five years, her team has conducted in-depth research on the molecular regulatory mechanisms of infection immunity, inflammation, and gastrointestinal tumors, discovering several proteins that regulate immune signal transduction. She has been recognized as a Young Changjiang Scholar by the Ministry of Education (2024), Hubei Provincial Young Top Talent (2021), Wuhan Young and Middle-aged Medical Backbone Talent (2019), Wuhan University Young Top Talent (2017), and Key Talent of Renmin Hospital of Wuhan University (2017). To date, she has published 14 SCI papers as the first or co-corresponding author, including 2 papers in Nature Communications (IF 14.8), 2 papers in Cell Molecular Immunology (IF 22.1), and 3 papers in Advanced Science (IF 16.8), as well as publications in PNAS, PLOS Pathogens, and The Journal of Immunology, among others. | |
| Selected Publications | |
|
1．Dong HP, Li Y, Tang Z, Wang P, Zhong B, Chu Q, Lin D. Combined
targeting of CCL7 and Flt3L to promote the expansion and infiltration of
cDC1s in tumors enhances T-cell activation and anti-PD-1 therapy
effectiveness in NSCLC. Cell Mol Immunol. 2023 Jul;20(7):850-853. doi:
10.1038/s41423-023-00991-5. Epub 2023 Mar 9. PMID: 36894615; PMCID:
PMC10310796.IF:21.8 2．Zhang ZD, Shi CR, Li FX, Gan H, Wei Y, Zhang Q, Shuai X, Chen M, Lin YL, Xiong TC, Chen X, Zhong B, Lin D. Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115. Cell Mol Immunol. 2024 Mar;21(3):275-291. doi: 10.1038/s41423-024-01131-3. Epub 2024 Jan 24. PMID: 38267694; PMCID: PMC10901794.IF:21.8 3．Xiong TC, Wei MC, Li FX, Shi M, Gan H, Tang Z, Dong HP, Liuyu T, Gao P, Zhong B, Zhang ZD, Lin D. The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS. Nat Commun. 2022 Oct 10;13(1):5973. doi: 10.1038/s41467-022-33671-5. PMID: 36217001; PMCID: PMC9551088.IF:14.7 4. Zhang M, Yang W, Wang P, Deng Y, Dong YT, Liu FF, Huang R, Zhang P, Duan YQ, Liu XD, Lin D, Chu Q, Zhong B. CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer. Nat Commun. 2020 Nov 30;11(1):6119. doi: 10.1038/s41467-020-19973-6. PMID: 33257678; PMCID: PMC7704643.IF:14.7 5. Wang P, Yang W, Guo H, Dong HP, Guo YY, Gan H, Wang Z, Cheng Y, Deng Y, Xie S, Yang X, Lin D, Zhong B. IL-36γ and IL-36Ra Reciprocally Regulate NSCLC Progression by Modulating GSH Homeostasis and Oxidative Stress-Induced Cell Death. Adv Sci (Weinh). 2021 Oct;8(19):e2101501. doi: 10.1002/advs.202101501. Epub 2021 Aug 8. PMID: 34369094; PMCID: PMC8498882.IF:14.3 6. Yang W, Dong HP, Wang P, Xu ZG, Xian J, Chen J, Wu H, Lou Y, Lin D, Zhong B. IL-36γ and IL-36Ra Reciprocally Regulate Colon Inflammation and Tumorigenesis by Modulating the Cell-Matrix Adhesion Network and Wnt Signaling. Adv Sci (Weinh). 2022 Apr;9(10):e2103035. doi: 10.1002/advs.202103035. Epub 2022 Feb 4. PMID: 35119210; PMCID: PMC8981487.IF:14.3 7. Zhang ZD, Li HX, Gan H, Tang Z, Guo YY, Yao SQ, Liuyu T, Zhong B, Lin D. RNF115 Inhibits the Post-ER Trafficking of TLRs and TLRs-Mediated Immune Responses by Catalyzing K11-Linked Ubiquitination of RAB1A and RAB13. Adv Sci (Weinh). 2022 May;9(16):e2105391. doi: 10.1002/advs.202105391. Epub 2022 Mar 28. PMID: 35343654; PMCID: PMC9165487.IF:14.3 8. Ye L, Zhang Q, Liuyu T, Xu Z, Zhang MX, Luo MH, Zeng WB, Zhu Q, Lin D, Zhong B. USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA. PLoS Pathog. 2019 Apr 3;15(4):e1007680. doi: 10.1371/journal.ppat.1007680. PMID: 30943264; PMCID: PMC6464240.IF:5.5 |
学术任职与荣誉
科研成果
| 出诊医生 | 星期一 | 星期二 | 星期三 | 星期四 | 星期五 | 星期六 | 星期日 | |||||||
| 上午 | 下午 | 上午 | 下午 | 上午 | 下午 | 上午 | 下午 | 上午 | 下午 | 上午 | 下午 | 上午 | 下午 | |
| 林丹丹 | ||||||||||||||
预约方式
武汉大学人民医院
湖北省人民医院