科室及职务
诊疗专长
| 姓名 | 梁伟 |
| 出生年月 | 1980年5月 |
| 单位 | 武汉大学人民医院肾内科 |
| 所属学科 | 临床医学-内科学 |
| 职务、职称及头衔 | 洪山院区肾内科主任，主任医师，副教授，硕士生导师 |
| dr.liangwei@whu.edu.cn | |
| 联系方式 | 027-88041911转82144或13971576532 |
| 研究方向 |
1.糖尿病肾病的能量代谢机制研究 2.水盐代谢与肾小管间质纤维化 |
| 个人简介 | |
| 主要从事肾脏疾病的防治与科研工作，主持国家自然科学基金3项、其他省部级课题2项，参编/译专著4部，在KI，JASN，Trends in Endocrinology and Metabolism，Metabolism等杂志发表SCI论文20余篇。目前正在培养硕士研究生1名。 | |
| 学术任职与荣誉 | |
|
国家自然科学基金函审专家 中国病理生理学会肾脏病专委会第一届、二届委员 中华医学会肾脏病分会第十一届委员会青年委员 中国医师协会肾脏内科医师分会第四届委员会青年委员 中国研究型医院学会肾脏病专业第二届委员会委员 湖北省医学生物免疫学会青委会委员 湖北省医学会肾脏病学分会青年学组副组长 武汉医学会肾脏病分会第六届委员会委员 武汉医学会肾脏病分会腹膜透析学组副组长 《临床肾脏病杂志》编委 《中华肾脏病杂志》审稿专家 |
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| 教育履历 | |
|
l2014/11~2018/06，德国弗莱堡大学医学院高血压与肾脏病科，博士后 l2006/09~2009/07，武汉大学人民医院内科学肾脏病专业，博士 l2003/09~2006/07，武汉大学人民医院内科学肾脏病专业，硕士 l1998/09~2003/07，武汉大学医学院临床医学系， 学士 |
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| 工作履历 | |
|
l2020/12~至今， 武汉大学人民医院肾内科，主任医师 l2019/12~至今， 武汉大学人民医院肾内科，副教授 l2013/12~2020/11，武汉大学人民医院肾内科，副主任医师 l2009/12~2013/11，武汉大学人民医院肾内科，主治医师 l2009/07~2009/11，武汉大学人民医院肾内科，住院医师 |
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| 成果获奖 | |
| 《肾小球足细胞损伤机制及诊治策略研究》2011年湖北省科技进步一等奖（排名第二） | |
| 代表性论著 | |
|
（1）Cao Y, Chen X, Zhu Z, Luo Z, Hao
Y, Yang X, Feng J, Zhang Z, Hu J, Jian Y, Zhu J,Liang
W, Chen Z. STING contributes to
lipopolysaccharide-induced tubular cell inflammation and pyroptosis by
activating endoplasmic reticulum stress in acute kidney injury. Cell Death
Dis. 2024 Mar 14;15(3):217. doi: 10.1038/s41419-024-06600-1. PMID: 38485717.（共同通讯，IF 9.0，1区TOP） （2）Hu H, Zhang Z, Liu Z, Chu F, Ran J,Liang W. Thickened Perirenal Fat Predicts Poor Renal Outcome in Patients with Immunoglobulin A Nephropathy: A Population- Based Retrospective Cohort Study. Kidney Dis (Basel). 2023 Oct 19;10(1):51-60. doi: 10.1159/000533507. PMID: 38322631; PMCID: PMC10843190.（通讯作者，IF 3.7，3区） （3）Zhang Z, Hu H, Luo Q, Yang K, Zou Z, Shi M,Liang W. Dihydroxyacetone phosphate accumulation leads to podocyte pyroptosis in diabetic kidney disease. J Cell Mol Med. 2024 Feb;28(3):e18073. doi: 10.1111/jcmm.18073. Epub 2023 Dec 8. PMID: 38063077; PMCID: PMC10844688.（通讯作者，IF 5.3，2区） （4）Bork T, Hernando-Erhard C,Liang W, Tian Z, Yamahara K, Huber TB. Cisplatin Nephrotoxicity Is Critically Mediated by the Availability of BECLIN1. Int J Mol Sci. 2024 Feb 22;25(5):2560. doi: 10.3390/ijms25052560. PMID: 38473806; PMCID: PMC10931997.（IF 5.6，1区） （5）Hu H,Liang W, Ding G. Ion homeostasis in diabetic kidney disease. Trends Endocrinol Metab. 2024 Feb;35(2):142-150. doi: 10.1016/j.tem.2023.09.009. Epub 2023 Oct 23. PMID: 37880052.（通讯作者，IF 10.9，1区TOP综述） （6）Hu H, Li W, Hao Y, Peng Z, Zou Z,Liang W. Baicalin ameliorates renal fibrosis by upregulating CPT1α-mediated fatty acid oxidation in diabetic kidney disease. Phytomedicine. 2024 Jan;122:155162. doi: 10.1016/j.phymed.2023.155162. Epub 2023 Oct 22. PMID: 37922789.（通讯作者，IF 7.9，1区TOP） （7）Hu J, Zhang Z, Hu H, Yang K, Zhu Z, Yang Q,Liang W. LRH-1 activation alleviates diabetes-induced podocyte injury by promoting GLS2-mediated glutaminolysis. Cell Prolif. 2023 Nov;56(11):e13479. doi: 10.1111/cpr.13479. Epub 2023 Apr 13. PMID: 37057309; PMCID: PMC10623971.（通讯作者，IF 8.5，1区TOP） （8）Chen Z, Zhu Z,Liang W, Luo Z, Hu J, Feng J, Zhang Z, Luo Q, Yang H, Ding G. Reduction of anaerobic glycolysis contributes to angiotensin II-induced podocyte injury with foot process effacement. Kidney Int. 2023 Apr;103(4):735-748. doi: 10.1016/j.kint.2023.01.007. Epub 2023 Jan 31. PMID: 36731609.（共同第一作者，IF 19.6，1区TOP） （9）Hu H,Liang W, Zhang Z, Liu Z, Chu F, Bao Y, Ran J, Ding G. The Utility of Perirenal Fat in Determining the Risk of Onset and Progression of Diabetic Kidney Disease. Int J Endocrinol. 2022 Nov 30;2022:2550744. doi:10.1155/2022/2550744. PMID: 36507087; PMCID: PMC9729039.（共同第一，共同通讯，IF 2.8，3区） （10）Chen Z,Liang W, Hu J, Zhu Z, Feng J, Ma Y, Yang Q, Ding G. Sirt6 deficiency contributes to mitochondrial fission and oxidative damage in podocytes via ROCK1-Drp1 signalling pathway. Cell Prolif. 2022 Oct;55(10):e13296. doi: 10.1111/cpr.13296. Epub 2022 Jul 17. PMID: 35842903; PMCID: PMC9528772.（共同第一作者，IF 8.5，1区TOP） （11）Luo Q,Liang W, Zhang Z, Zhu Z, Chen Z, Hu J, Yang K, Chi Q, Ding G. Compromised glycolysis contributes to foot process fusion of podocytes in diabetic kidney disease: Role of ornithine catabolism. Metabolism. 2022 Sep;134:155245. doi: 10.1016/j.metabol. 2022. 155245. Epub 2022 Jun 30. PMID:35780908.（共同第一，共同通讯，IF 9.8，1区TOP） （12）Zhang Z,Liang W, Luo Q, Hu H, Yang K, Hu J, Chen Z, Zhu J, Feng J, Zhu Z, Chi Q, Ding G. PFKP Activation Ameliorates Foot Process Fusion in Podocytes in Diabetic Kidney Disease. Front Endocrinol (Lausanne). 2022 Jan 14;12:797025. doi: 10.3389/fendo.2021.797025. PMID: 35095764; PMCID: PMC8794994.（共同第一，共同通讯，IF 5.2，1区） （13）Liang W, Yamahara K, Hernando-Erhard C, Lagies S, Wanner N, Liang H, Schell C, Kammerer B, Huber TB, Bork T. A reciprocal regulation of spermidine and autophagy in podocytes maintains the filtration barrier. Kidney Int. 2020 Dec;98(6):1434-1448. doi: 10.1016/j.kint.2020.06.016. Epub 2020 Jun 27. PMID: 32603735.（第一作者，IF 19.6，1区TOP） （14）Bork T,Liang W, Yamahara K, Lee P, Tian Z, Liu S, Schell C, Thedieck K, Hartleben B, Patel K, Tharaux PL, Lenoir O, Huber TB. Podocytes maintain high basal levels of autophagy independent of mtor signaling. Autophagy. 2020 Nov;16(11):1932-1948. doi: 10.1080/15548627.2019.1705007. Epub 2019 Dec 23. PMID: 31865844; PMCID: PMC7595647.（IF 13.3，1区） （15）Brinkkoetter PT, Bork T, Salou S,Liang W, Mizi A, Özel C, Koehler S, Hagmann HH, Ising C, Kuczkowski A, Schnyder S, Abed A, Schermer B, Benzing T, Kretz O, Puelles VG, Lagies S, Schlimpert M, Kammerer B, Handschin C, Schell C, Huber TB. Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics. Cell Rep. 2019 Apr 30;27(5):1551-1566.e5. doi: 10.1016/j.celrep.2019.04.012. PMID: 31042480; PMCID: PMC6506687.（IF 8.8，1区TOP） （16）Zschiedrich S, Bork T,Liang W, Wanner N, Eulenbruch K, Munder S, Hartleben B, Kretz O, Gerber S, Simons M, Viau A, Burtin M, Wei C, Reiser J, Herbach N, Rastaldi MP, Cohen CD, Tharaux PL, Terzi F, Walz G, Gödel M, Huber TB. Targeting mTOR Signaling Can Prevent the Progression of FSGS. J Am Soc Nephrol. 2017 Jul;28(7):2144-2157. doi: 10.1681/ASN.2016050519. Epub 2017 Mar 7. PMID: 28270414; PMCID: PMC5491276.（共同第一作者，IF 13.6，1区TOP） |
| Name | WEI LIANG |
| Date of birth | May，1980 |
| Department | Department of Nephrology, Renmin Hospital, Wuhan University. |
| Title | Director, Associate Professor |
| dr.liangwei@whu.edu.cn | |
| TEL | 027-88041911转82144 or 13971576532 |
| Research Direction | |
|
1. Mechanisms of metabolism disorder in diabetic
kidney disease 2. Mechanisms of sodium disorder in tubular-intersitial fibrosis |
|
| Personal Profile | |
| He is involved in the clinical diagnosis and basic research of chronic kidney diseases, with a particular focus on diabetic kidney disease. His primary focus has been on investigating the characteristics and metabolism disorder of podocytes, with funding from the National Natural Science Foundation of China (NSFC, 3 items) and other local government projects. The originality of his study encompasses: 1. Spermidine, the byproduct of autophagy degradation, has the capacity to increase the activity of transcript factor MAFB, forming a positive feedback loop to maintain autophagy at high level in podocyte. 2.The aerobic glycolysis is the primary energy source in podocytes. 3. Metabolic reprogramming occurs in podocyte in response to damage via mTOR signaling. Currently, he has published 20 SCI papers in high impact journals. | |
| Selected Publications | |
|
（1）Cao Y, Chen X, Zhu Z, Luo Z, Hao
Y, Yang X, Feng J, Zhang Z, Hu J, Jian Y, Zhu J,Liang
W, Chen Z. STING contributes to
lipopolysaccharide-induced tubular cell inflammation and pyroptosis by
activating endoplasmic reticulum stress in acute kidney injury. Cell Death
Dis. 2024 Mar 14;15(3):217. doi: 10.1038/s41419-024-06600-1. PMID: 38485717.（共同通讯，IF 9.0，1区TOP） （2）Hu H, Zhang Z, Liu Z, Chu F, Ran J,Liang W. Thickened Perirenal Fat Predicts Poor Renal Outcome in Patients with Immunoglobulin A Nephropathy: A Population- Based Retrospective Cohort Study. Kidney Dis (Basel). 2023 Oct 19;10(1):51-60. doi: 10.1159/000533507. PMID: 38322631; PMCID: PMC10843190.（通讯作者，IF 3.7，3区） （3）Zhang Z, Hu H, Luo Q, Yang K, Zou Z, Shi M,Liang W. Dihydroxyacetone phosphate accumulation leads to podocyte pyroptosis in diabetic kidney disease. J Cell Mol Med. 2024 Feb;28(3):e18073. doi: 10.1111/jcmm.18073. Epub 2023 Dec 8. PMID: 38063077; PMCID: PMC10844688.（通讯作者，IF 5.3，2区） （4）Bork T, Hernando-Erhard C,Liang W, Tian Z, Yamahara K, Huber TB. Cisplatin Nephrotoxicity Is Critically Mediated by the Availability of BECLIN1. Int J Mol Sci. 2024 Feb 22;25(5):2560. doi: 10.3390/ijms25052560. PMID: 38473806; PMCID: PMC10931997.（IF 5.6，1区） （5）Hu H,Liang W, Ding G. Ion homeostasis in diabetic kidney disease. Trends Endocrinol Metab. 2024 Feb;35(2):142-150. doi: 10.1016/j.tem.2023.09.009. Epub 2023 Oct 23. PMID: 37880052.（通讯作者，IF 10.9，1区TOP综述） （6）Hu H, Li W, Hao Y, Peng Z, Zou Z,Liang W. Baicalin ameliorates renal fibrosis by upregulating CPT1α-mediated fatty acid oxidation in diabetic kidney disease. Phytomedicine. 2024 Jan;122:155162. doi: 10.1016/j.phymed.2023.155162. Epub 2023 Oct 22. PMID: 37922789.（通讯作者，IF 7.9，1区TOP） （7）Hu J, Zhang Z, Hu H, Yang K, Zhu Z, Yang Q,Liang W. LRH-1 activation alleviates diabetes-induced podocyte injury by promoting GLS2-mediated glutaminolysis. Cell Prolif. 2023 Nov;56(11):e13479. doi: 10.1111/cpr.13479. Epub 2023 Apr 13. PMID: 37057309; PMCID: PMC10623971.（通讯作者，IF 8.5，1区TOP） （8）Chen Z, Zhu Z,Liang W, Luo Z, Hu J, Feng J, Zhang Z, Luo Q, Yang H, Ding G. Reduction of anaerobic glycolysis contributes to angiotensin II-induced podocyte injury with foot process effacement. Kidney Int. 2023 Apr;103(4):735-748. doi: 10.1016/j.kint.2023.01.007. Epub 2023 Jan 31. PMID: 36731609.（共同第一作者，IF 19.6，1区TOP） （9）Hu H,Liang W, Zhang Z, Liu Z, Chu F, Bao Y, Ran J, Ding G. The Utility of Perirenal Fat in Determining the Risk of Onset and Progression of Diabetic Kidney Disease. Int J Endocrinol. 2022 Nov 30;2022:2550744. doi:10.1155/2022/2550744. PMID: 36507087; PMCID: PMC9729039.（共同第一，共同通讯，IF 2.8，3区） （10）Chen Z,Liang W, Hu J, Zhu Z, Feng J, Ma Y, Yang Q, Ding G. Sirt6 deficiency contributes to mitochondrial fission and oxidative damage in podocytes via ROCK1-Drp1 signalling pathway. Cell Prolif. 2022 Oct;55(10):e13296. doi: 10.1111/cpr.13296. Epub 2022 Jul 17. PMID: 35842903; PMCID: PMC9528772.（共同第一作者，IF 8.5，1区TOP） （11）Luo Q,Liang W, Zhang Z, Zhu Z, Chen Z, Hu J, Yang K, Chi Q, Ding G. Compromised glycolysis contributes to foot process fusion of podocytes in diabetic kidney disease: Role of ornithine catabolism. Metabolism. 2022 Sep;134:155245. doi: 10.1016/j.metabol. 2022. 155245. Epub 2022 Jun 30. PMID:35780908.（共同第一，共同通讯，IF 9.8，1区TOP） （12）Zhang Z,Liang W, Luo Q, Hu H, Yang K, Hu J, Chen Z, Zhu J, Feng J, Zhu Z, Chi Q, Ding G. PFKP Activation Ameliorates Foot Process Fusion in Podocytes in Diabetic Kidney Disease. Front Endocrinol (Lausanne). 2022 Jan 14;12:797025. doi: 10.3389/fendo.2021.797025. PMID: 35095764; PMCID: PMC8794994.（共同第一，共同通讯，IF 5.2，1区） （13）Liang W, Yamahara K, Hernando-Erhard C, Lagies S, Wanner N, Liang H, Schell C, Kammerer B, Huber TB, Bork T. A reciprocal regulation of spermidine and autophagy in podocytes maintains the filtration barrier. Kidney Int. 2020 Dec;98(6):1434-1448. doi: 10.1016/j.kint.2020.06.016. Epub 2020 Jun 27. PMID: 32603735.（第一作者，IF 19.6，1区TOP） （14）Bork T,Liang W, Yamahara K, Lee P, Tian Z, Liu S, Schell C, Thedieck K, Hartleben B, Patel K, Tharaux PL, Lenoir O, Huber TB. Podocytes maintain high basal levels of autophagy independent of mtor signaling. Autophagy. 2020 Nov;16(11):1932-1948. doi: 10.1080/15548627.2019.1705007. Epub 2019 Dec 23. PMID: 31865844; PMCID: PMC7595647.（IF 13.3，1区） （15）Brinkkoetter PT, Bork T, Salou S,Liang W, Mizi A, Özel C, Koehler S, Hagmann HH, Ising C, Kuczkowski A, Schnyder S, Abed A, Schermer B, Benzing T, Kretz O, Puelles VG, Lagies S, Schlimpert M, Kammerer B, Handschin C, Schell C, Huber TB. Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics. Cell Rep. 2019 Apr 30;27(5):1551-1566.e5. doi: 10.1016/j.celrep.2019.04.012. PMID: 31042480; PMCID: PMC6506687.（IF 8.8，1区TOP） （16）Zschiedrich S, Bork T,Liang W, Wanner N, Eulenbruch K, Munder S, Hartleben B, Kretz O, Gerber S, Simons M, Viau A, Burtin M, Wei C, Reiser J, Herbach N, Rastaldi MP, Cohen CD, Tharaux PL, Terzi F, Walz G, Gödel M, Huber TB. Targeting mTOR Signaling Can Prevent the Progression of FSGS. J Am Soc Nephrol. 2017 Jul;28(7):2144-2157. doi: 10.1681/ASN.2016050519. Epub 2017 Mar 7. PMID: 28270414; PMCID: PMC5491276.（共同第一作者，IF 13.6，1区TOP） |
学术任职与荣誉
科研成果
| 出诊医生 | 星期一 | 星期二 | 星期三 | 星期四 | 星期五 | 星期六 | 星期日 | |||||||
| 上午 | 下午 | 上午 | 下午 | 上午 | 下午 | 上午 | 下午 | 上午 | 下午 | 上午 | 下午 | 上午 | 下午 | |
| 梁伟 | ||||||||||||||
预约方式
武汉大学人民医院
湖北省人民医院